How does chloramphenicol cause GREY baby syndrome?

Does chloramphenicol cause blue baby syndrome?

Chloramphenicol accumulates in the baby, causing hypotension (low blood pressure), cyanosis (blue coloring of lips, nail beds, and skin from lack of oxygen in the blood), and often death. Chloramphenicol is therefore usually not given to newborns or premature babies.

Why does chloramphenicol cause neonate toxicity?

Chloramphenicol and thiamphenicol

Infants given large doses may develop exceedingly high plasma levels of the drug because of their immature conjugation and excretion mechanisms.

Which drug can causes gray baby syndrome?

Gray baby syndrome is a condition in which an infant experiences a life-threatening reaction to the antibiotic Chloramphenicol. It is more prevalent in premature infants since an adverse reaction is directly related to the liver’s ability to break down and process the medication.

What antibiotic causes GREY baby syndrome?

Gray baby syndrome is an adverse reaction to chloramphenicol that is characterized by abdominal distention, hemodynamic collapse, and ashen-gray skin discoloration in neonates.

Can chloramphenicol be given to babies?

Chloramphenicol eye drops can be safely administered to children aged 0 to 2 years where antibiotic eye drop treatment is indicated.

What is red baby syndrome?

Red Baby Syndrome is a new disease seen in infants and young children. Dramatic onset of clinical symptoms with high intensity, short duration and lack of similarity with other cutaneous lesions makes it distinct. Of 50 such patients studied over a period of 5 years, half were below one year of age.

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What are the toxic effects of chloramphenicol?

Chloramphenicol can be fatal in an overdose; this usually occurs with intravenous administration of the drug and is more likely to affect infants. Symptoms of poisoning include nausea and vomiting, abdominal distension, metabolic acidosis, hypotension, hypothermia, cardiovascular collapse, and coma.

What are the contraindications of chloramphenicol?

Who should not take CHLORAMPHENICOL SOD SUCCINATE?

  • hereditary liver metabolism disorder.
  • decreased function of bone marrow.
  • low blood counts due to bone marrow failure.
  • anemia.
  • decreased blood platelets.
  • low levels of granulocytes, a type of white blood cell.

How long can I use chloramphenicol?

Do not use them for more than 5 days, unless your doctor tells you to. This is because your eyes can become more sensitive or you could get another eye infection. Eye ointment – use the ointment until the eye appears normal and for 2 days afterwards. Do not use it for more than a week, unless your doctor tells you to.