Which beta blocker is not safe in pregnancy?
Conclusions The authors found that exposure to β-blockers during pregnancy was associated with being born SGA, preterm birth and perinatal mortality. Our findings show that labetalol is not safer than other β-blockers during pregnancy.
Are beta-blockers safe during pregnancy?
β-Blockers are the most commonly used class of medication for treating cardiac conditions in pregnant women. Despite the common use of this class of medication, data that support its safety are limited. β-Blockers cross the placenta and potentially can cause physiological changes in the fetus.
Are beta-blockers contraindicated in pregnancy?
Despite the increased use of beta-blockers in pregnancy, there is only limited information on their possible teratogenic effects. Beta-blockers could reduce uteroplacental blood flow and could therefore lead to congenital anomalies in the offspring.
Does propranolol cross the placenta?
Albumin binding had no significant effect on diffusion when equal concentrations were used in the two perfusion circuits. With increased albumin concentration on the fetal side an acceleration of the diffusion of propranolol could be shown. Propranolol and labetalol showed considerable binding to placental tissue.
Is propranolol safe in early pregnancy?
Pregnancy and breastfeeding
Propranolol is not thought to be harmful during pregnancy, but it is not possible to be certain. If you’re trying to get pregnant or you’re already pregnant, talk to your doctor about the benefits and possible harms of taking propranolol. There may be other medicines that are safer for you.
Can beta blockers cause miscarriage?
Can taking propranolol in pregnancy cause miscarriage? A single study provided no evidence that use of propranolol in early pregnancy was linked to an increased risk of miscarriage. No further studies have assessed miscarriage rates in women taking propranolol and more research into this subject is therefore required.
Which blood pressure medication is safe during pregnancy?
Methyldopa has been used for decades to treat high blood pressure in pregnancy and it appears to be safe. Labetalol has been extensively studied and has become increasing prescribed in pregnancy. Labetalol is now commonly used as a first-line treatment choice.
Do beta blockers decrease milk supply?
In general, beta blockers that are considered to pose less risk to a breastfeeding infant have, or are predicted to have, lower levels in breast milk (due to a high degree plasma protein binding, low lipid solubility and a short half-life) and relatively low renal excretion.
How long can you stay on beta blockers?
Guidelines recommend beta blocker therapy for three years, but that may not be necessary. Beta blockers work by blocking the effects of the hormone epinephrine, also called adrenaline. Taking beta blockers reduces your heart rate and blood pressure. This eases the workload on your heart and improves blood flow.
Which antihypertensive is contraindicated in pregnancy?
ACE-Is and angiotensin receptor blockers should be avoided in all trimesters; when administered in the second and third trimesters, they are associated with a characteristic fetopathy, neonatal renal failure, and death, and, thus, are contraindicated.
Why diuretics are contraindicated in pregnancy?
Diuretics do not cause fetal malformations but are generally avoided in pregnancy, as they prevent the physiologic volume expansion seen in normal pregnancy. They may be used in states of volume-dependent hypertension, such as renal or cardiac disease.